CHANGES IN THE FUNCTIONAL STATUS OF THE ADRENAL CORTEX AND CLINICAL FEATURES IN OVERDUE NEWBORNS WITH FREQUENT EDEMA

This study investigates adrenal cortical dysfunction and its role in recurrent edema in post-term neonates (≥42 weeks gestation). The findings reveal altered cortisol and aldosterone levels, suggesting HPA axis immaturity, fetal stress adaptation, and RAAS dysregulation as key contributors to fluid imbalance. Elevated cortisol levels in some neonates indicate chronic stress response, while low levels in others suggest transient adrenal insufficiency. Aldosterone abnormalities were associated with sodium retention, electrolyte imbalances, and edema formation. These findings underscore the importance of early endocrine assessment in post-term neonates with unexplained fluid retention.